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Recognizing the Signs of Hormonal Changes in Men Over 40

15 December 2025

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Many men notice changes in their bodies and moods as they get older. Things like feeling more tired than usual, gaining a bit of weight or having less interest in sex are often dismissed as just part of aging. While these can be normal parts of getting older, they can also be signs that something more is going on with your hormones. 

We speak to Jonathan Meier, M.D., a family medicine physician at INTEGRIS Health Medical Group Rose Creek, to learn more. 

"My goal as a primary care physician is to collaborate with my patients to address their current health concerns and proactively prevent future problems," Meier says. "For those experiencing symptoms of age-related hormonal changes, the best first step is to consult with your primary care doctor. Getting that expert guidance early is key to minimizing long-term health effects."

Learning about the basics of andropause

What to know: Andropause, sometimes called male menopause, is a term used to describe the age-related decline in testosterone and other hormones in men. Unlike female menopause, which involves a rapid drop in hormones, andropause tends to be a more gradual process. This slow change can make the symptoms subtle at first, but they can have a significant impact on a man’s quality of life over time. 

  • Andropause typically begins in a man’s 40s, but it can start earlier or later.
  • The hormonal decline is gradual, often spanning several years or even decades.
  • Key hormones involved include testosterone and dehydroepiandrosterone (DHEA). 

Understanding these changes is important for maintaining overall well-being. Recognizing andropause symptoms can lead to conversations with your doctor about potential treatments and lifestyle adjustments that can help manage the effects of these hormonal shifts. 

What are androgens, and what do they do? 

The basics: Androgens are a group of hormones that play a crucial role in male traits and reproductive activity. Testosterone is the most well-known androgen, but there are others like androstenedione and DHEA.  

  • Androgens are produced primarily in the testes but also in the adrenal glands.
  • They are essential for muscle mass, bone density and the production of red blood cells.
  • These hormones also influence mood, energy levels and cognitive function. 

Beyond physical traits, androgens are vital for a man’s overall health and sense of well-being. Proper levels of these hormones contribute to a healthy libido, normal erectile function and even emotional stability. When androgen levels decline, it can affect multiple systems in the body, leading to a range of symptoms. 

Why does testosterone decrease in men over 40? 

Why it happens: The testosterone decline after 40 is a natural part of the aging process for many men. As men get older, the testicles produce less testosterone and the body’s production of other hormones that stimulate testosterone also slows down. This gradual decrease is a key feature of andropause. 

  • After age 30, testosterone levels typically decrease by about 1 percent per year.
  • Lifestyle factors such as obesity, lack of exercise and poor diet can accelerate this decline.
  • Certain medical conditions like diabetes, sleep apnea and thyroid problems can also contribute to low testosterone. 

Chronic stress is another significant factor. High levels of the stress hormone cortisol can interfere with testosterone production. This is why managing stress through techniques like mindfulness, exercise and adequate sleep is important for hormonal health.  

Common signs of low testosterone 

Recognizing the signs: The symptoms of male hormone imbalance can vary widely from one person to another and often develop slowly. Common signs of low testosterone include changes in sexual function, physical appearance and emotional well-being. 

  • Many men experience a noticeable decrease in their desire for sex.
  • Physical changes like hair loss and increased body fat are also common.
  • Emotional shifts such as feelings of sadness or irritability can occur.
  • Men may also find it harder to concentrate or feel mentally sharp.
  • A general lack of energy and motivation is a frequent complaint. 

Reduced sex drive and erectile dysfunction are often the most recognized signs of low testosterone. A lower libido means you might think about sex less often and have a reduced desire for sexual activity.

  • Difficulty achieving or maintaining an erection
  • A noticeable reduction in sexual interest
  • Reduced levels of satisfaction from sexual activities  

Hair loss, especially around the armpits and pubic area, can be another sign of hormonal changes. Testosterone plays a role in hair growth on the body, so a decline in this hormone can lead to thinning or loss of body hair. 

  • Thinning of hair on the chest and back
  • Slower growth of facial hair requiring less frequent shaving
  • Noticeable hair loss in the genital region and underarms 

Hot flashes are often associated with female menopause, but they can also affect men with low testosterone. These are sudden feelings of intense warmth often accompanied by sweating and a flushed face. 

  • Sudden and intense waves of heat in the upper body
  • Excessive sweating, particularly at night
  • A rapid heartbeat or feelings of anxiety during a hot flash 

A low sperm count is another potential consequence of decreased testosterone levels. Testosterone is essential for the production of sperm, so lower levels of the hormone can lead to reduced fertility

  • Difficulty conceiving a child with a partner
  • A diagnosis of low sperm count following fertility testing
  • This is often a silent symptom discovered only when trying to have children 

Depression and other mood changes can be linked to hormonal imbalances in men. Low testosterone can affect the chemicals in the brain that regulate mood, leading to feelings of sadness, irritability or a general lack of interest in activities you once enjoyed. 

  • Persistent feelings of sadness or hopelessness
  • Increased irritability or frequent mood swings
  • Loss of interest in hobbies and social activities 

Problems with memory and concentration are also common complaints among men with low testosterone. Some men report feeling a sense of “brain fog,” making it harder to focus on tasks or remember information. 

  • Difficulty concentrating at work or during conversations
  • Forgetting appointments or important details more frequently
  • A general feeling of mental slowness or lack of sharpness 

Increased body fat, particularly around the abdomen, is a physical sign of declining testosterone. Testosterone helps regulate fat distribution and metabolism, so lower levels can lead to weight gain and changes in body composition. 

  • An increase in belly fat despite no significant changes in diet or exercise
  • A softer or less defined physique
  • Difficulty losing weight even with consistent effort 

Decreased strength and muscle mass can be a frustrating symptom for many men. Testosterone is crucial for building and maintaining muscle, so a decline can result in a loss of physical strength and endurance. 

  • Feeling weaker during workouts or daily activities
  • A visible reduction in muscle size and tone
  • Longer recovery times after physical exertion 

Can low testosterone be a sign of a more serious health problem? 

Key points: While low testosterone is often a part of the natural aging process, it can sometimes be a red flag for other underlying health issues. It is important to see a doctor to rule out more serious conditions that could be causing your symptoms. A thorough evaluation can help determine the root cause of your hormonal imbalance. 

  • Conditions like pituitary gland problems or testicular injury can cause low testosterone.
  • Chronic diseases such as liver or kidney disease can also impact hormone levels.
  • In some cases, low testosterone may be linked to genetic disorders. 

A comprehensive medical check-up is essential. Your doctor can perform blood tests to measure your hormone levels and may recommend further testing to investigate any other potential health concerns. This ensures you receive the most appropriate and effective treatment for your specific situation. 

How is low testosterone treated? 

The treatments: Treatment for low testosterone involves lifestyle changes that can make a significant difference in symptoms. Regular exercise, particularly strength training, can help boost testosterone levels naturally. A balanced diet rich in nutrients like zinc and vitamin D is also beneficial. Weight management, smoking cessation, stress reduction and adequate sleep are also essential.  

If these lifestyle modifications fail to improve your symptoms, hormone replacement therapy (HRT) will likely be considered to restore hormone levels to a normal range. This therapy can be administered in various forms, including gels, patches, injections or pellets implanted under the skin. The best option for you will depend on your lifestyle preferences and medical history. 

  • Testosterone gels are applied daily to the skin.
  • Injections are typically given every one to two weeks.
  • Pellets provide a steady release of hormones over several months. 

In addition to lifestyle modification and HRT, psychological support through counseling and support groups can also help manage mood and cognitive symptoms. Your doctor can help you create a holistic treatment plan that addresses both your hormonal health and overall well-being. 

Find a doctor at INTEGRIS Health now 

Next steps: Navigating the signs of hormonal changes can be challenging, but you don’t have to do it alone. The dedicated health care professionals at INTEGRIS Health are here to provide expert guidance and personalized care. If you are experiencing any of the symptoms discussed here, it may be time to speak with a doctor.

Reach out to an INTEGRIS Health provider today to schedule a consultation and start your journey toward feeling your best again.

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